To develop a novel imaging-guided precision medicine for glioblastoma multiforme

Conclusions and Recommendations:

Under the support of the Churchill Fellowship project, I visited several universities and research institutes and established new research collaboration on GBM treatment and assessment. The main objectives of my fellowship were to gain deep knowledge on GBM tumour responses to chemotherapy and combination treatment by incorporating imaging capability in the drug delivery platform, to understand how NPs can cross over the BBB, and to define the assessment of drug response during the treatment.

Therefore, it can achieve precise treatment for the patients and guide personalised and appropriate interventions at the critical early stage of GBM cancer to improve the survival rate.

Throughout this Fellowship, I was able to consolidate research relationships with my collaborators on emerging research interest.

Further, I had an opportunity to build up new research collaboration with experts on bioimaging with Prof. Wang and Li at Suzhou Institute of Nano-Tech and Nano-Bionics and Soochow University, on nanoparticle-cell interaction with Prof. Wang at Shenzhen Institutes of Advanced Technology, and on microfluidics for cancer models with Prof. Jiang from Southern University of Science and Technology.

These new research collaborations would advance my research on cancer therapy and my career development. I also shared my understanding and knowledge with them, which is mutual benefit for GBM research.

Finally, I was able to apply for Discovery Project 2019 from Australian Research Council with the collaborators as partner investigators this year.

Additionally I have gained some clinical experience on cancer therapy and diagnosis. After completing the fellowship, we will continuously work on researching:

• Optimisation of LCPs with drugs/gene and imaging agents.

• In-vitro efficiency of chemo-gene combinational therapy delivered by LCPs for GBM Cellular uptake study of NIR probe-conjugated LCPs.

• In vivo study of the efficiency of chemo-gene combinational therapy and assessment of the treatment using NIR probe-conjugated LCPs.

Keywords: Brain cancer, therapy, nanoparticles, bioimaging, malignant tumor, biotechnology.